Causal association of antibody-mediated immune responses to infectious disease agents with lung cancer: a Mendelian randomization study.

ABSTRACT:

Background

There is a causal relationship between many non-communicable diseases and other infectious diseases. However, the exact relationship between lung cancer and the immune response to antibodies associated with viral diseases is unclear. Compared with other traditional methods, Mendelian randomization (MR) studies reduce the influence of confounding factors, thus improving the accuracy of the results. This study used MR to investigate the relationship between lung cancer and its subtypes, and the antibody immune response.

Methods

A two-sample MR method was employed to examine the association between lung cancer, its subtypes, and antibody-mediated immunity linked to 46 infectious diseases. The instrumental variables were single nucleotide polymorphisms associated with

SUBMITTER: Liang G 

PROVIDER: S-EPMC12214232 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature