Comparative analysis of codon usage bias and host adaptation across avian metapneumovirus genotypes.

ABSTRACT: Avian metapneumovirus (aMPV) is a significant pathogen affecting poultry worldwide, causing respiratory disease and economic losses. This study investigated the genetic and evolutionary differences among aMPV genotypes through codon usage bias analysis. Using whole-genome and F gene sequences, we assessed phylogenetic relationships, codon usage patterns, evolutionary pressures, and host adaptation. Our results indicate clear genotype differentiation in the phylogenetic tree, with Group C identified as the earliest diverging lineage of aMPV. The F gene exhibits independent evolutionary trajectories, reflecting distinct selective pressures. Codon usage bias varies across genotypes and is primarily driven by selection pressure, with Groups B and C experiencing stronger selective constraints.

SUBMITTER: Shi S 

PROVIDER: S-EPMC12214266 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature