Elevated mevalonolactone from Ruminococcus torques contributes to metabolically unhealthy obesity development.

ABSTRACT: Obese individuals are categorized as either "Metabolically Unhealthy Obesity" (MUO) or "Metabolically Healthy Obesity" (MHO) based on their insulin resistance and metabolic disorders. However, the intrinsic mechanism remains largely unknown. By examining gut microbiota and fecal metabolome of patients with MUO and MHO, we identified intestinal microorganism Ruminococcus torques (R. torques) and its metabolite mevalonolactone (MVL) as risk factors for insulin resistance and metabolic disorders. Both R. torques and MVL administration result in the MUO phenotype in mice. In general, MVL is an intermediate metabolite in the eukaryotic mevalonate (MVA) pathway; however, we found that the prokaryote R. torques has the potential to produce MVL. We further showed that MVL could directly bind to th

SUBMITTER: Nie HY 

PROVIDER: S-EPMC12214271 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature