Utilizing depression symptom-based phenotypes to explore ketamine treatment response in major depression: The Bio-K multicenter trial.

ABSTRACT:

Background

Previous work has identified four correlated factors (depression phenotypes) using the Montgomery-Åsberg Depression Rating Scale (MADRS)- Sadness, Negative Thoughts, detachment/Interest and Activity (IA), and Neurovegetative. We explored treatment responses to ketamine based on these 4 phenotypes in treatment resistant depression (TRD).

Methods

This is a secondary analysis of data from an open-label multi-center, clinical trial (BioK) examining biomarkers of treatment response, that enrolled 75 patients (ages 18-65 years old) with treatment-resistant unipolar or bipolar depression, excluding those with an active substance use disorder, psychosis, and unstable medical conditions. Pre-existing treatments were continued. Participants received 3 IV ketamine infusions

SUBMITTER: Penaluna BK 

PROVIDER: S-EPMC12214476 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature