Trimetazidine stimulates intracellular Ca²⁺ transients and zebrafish locomotor activity in spinal neurons.

ABSTRACT: The metabolic modulator trimetazidine (TMZ) is an antianginal recently found to improve skeletal muscle performance in mice models of sarcopenia and of amyotrophic lateral sclerosis (ALS). The mechanism underlying the effect of TMZ on locomotor activity has been proposed to rely on its ability to enhance metabolic efficiency with a consequent improvement of myogenesis and of neuromuscular junction (NMJ) and muscle function. However, although promising and therefore under clinical trials, the mechanism of action of TMZ has not been clearly disclosed; here we hypothesized that it might involve the modulation of neuronal Ca²⁺ flows. We studied the effect of TMZ on Ca²⁺ dynamics in vivo, by using the transgenic zebrafish line Tg(neurod1:GCaMP6f) in which the neuronal expr

SUBMITTER: Bernardi S 

PROVIDER: S-EPMC12214544 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature