Regulatory T cells and matrix-producing cancer associated fibroblasts contribute on the immune resistance and progression of prognosis related tumor subtypes in ccRCC.

ABSTRACT: Clear cell renal cell carcinoma (ccRCC) is a prevalent malignant tumor in the field of urology. The effect of cell heterogeneity on the prognosis and reaction to treatment of ccRCC in large populations is still unclear. By analyzing public single cell RNA-sequencing and bulk RNA-sequencing data with the Scissor algorithm, we have identified three distinct prognosis related cancer cell subtypes which play an indispensable role on tumor metastasis, immune response and proliferation respectively. Besides, regulatory T cells (Tregs) and matrix producing cancer associated fibroblasts (matCAFs) were also recognized as crucial cell subtypes in the tumor microenvironment (TME). Moreover, potential interactions between Scissor + cells and other cells in TME were investigated to uncover regulatory m

SUBMITTER: Zhang C 

PROVIDER: S-EPMC12214632 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature