Identification of aging-related biomarkers and immune infiltration analysis in renal stones by integrated bioinformatics analysis.

ABSTRACT: Renal stones (RS) are common urologic condition with unclear pathogenesis. Role of aging-related differentially expressed genes (ARDEGs) in RS remains poorly understood. This study aims to identify potential aging-related biomarkers for RS, explore the functions of aging-associated genes, and investigate the immunological microenvironment in RS. ARDEGs were collected from the GEO, GeneCards, and Molecular Signatures databases. The roles of ARDEGs were analyzed using Gene Ontology (GO) enrichment analysis. Key genes were identified using machine learning methods. Immune infiltration in RS was assessed using the CIBERSORT and ssGSEA algorithms. A total of 22 ARDEGs were identified through analysis, including 9 up-regulated and 13 down-regulated genes. GO enrichment analysis revealed that the

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12214660 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature