Mitigating cardiac allograft vasculopathy in a murine model via CD40-TRAF6 blockade and cyclosporin A synergy.

ABSTRACT: The interactions between CD40 and tumor necrosis factor receptor-associated factor 6 (TRAF6) are implicated in chronic inflammation and fibrosis. Given their poorly understood role in chronic transplant rejection, our study focused on investigating the CD40-TRAF6 interactions in murine models of cardiac transplantation, particularly in relation to cardiac allograft vasculopathy (CAV). We established murine heart transplantation models using BALB/C to C57BL/6 and H-2bm12 to C57BL/6 pairings. A specific antagonist for TRAF6 was administered post-transplantation, either alone or in combination with cyclosporin A (CsA). We analyzed cells infiltrating the cardiac allografts and splenic immune cells. Additionally, We explore the potential mechanistic effects of TRAF6 inhibition in CAV by bone ma

SUBMITTER: Huang Y 

PROVIDER: S-EPMC12214768 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature