Effect of enhanced early life nutrition on the molecular regulation of anterior pituitary function in Holstein Friesian bull calves.

ABSTRACT: Enhanced early-life nutrition is known to induce precocious reproductive development in the bull calf, mediated through gonadotropin releasing hormone (GnRH) stimulated gonadotropin pulsatility in the anterior pituitary gland. The objective of this study was to evaluate transcriptomic and proteomic responses within the anterior pituitary of Holstein-Friesian bull calves offered different planes of nutrition during early life. Bull calves were offered either a high (HI; n = 15) or moderate (MOD; n = 15) plane of nutrition between 2-12 weeks of age and subsequently euthanised at 12 weeks of age. The anterior pituitary tissue was harvested from all calves and miRNAseq, mRNAseq and proteomic analyses undertaken. High diet calves displayed greater growth rates compared to MOD calves (P < 0.001)

SUBMITTER: Keogh K 

PROVIDER: S-EPMC12214817 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature