Developed a knowledge base of risk factors for postoperative cognitive dysfunction: a retrospective database study.

ABSTRACT: Postoperative cognitive dysfunction (POCD), a heterogeneous spectrum of surgery/anesthesia-associated neurocognitive impairments, represents a critical clinical challenge due to its associations with prolonged hospitalization, increased mortality, and accelerated long-term cognitive deterioration. The development of targeted perioperative management strategies fundamentally depends on systematic risk factor identification, though current research remains hampered by significant heterogeneity and incomplete evidence synthesis across observational studies. To address this knowledge gap, we constructed the first panoramic knowledge base integrating multidimensional POCD risk factors through systematic analysis of 2,837 PubMed-indexed clinical studies (1991-20 May 2024). Utilizing a rigorous p

SUBMITTER: Tang N 

PROVIDER: S-EPMC12214832 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature