Comparing the metabolomic landscape of polycystic ovary syndrome within urban and rural environments.

ABSTRACT:

Background

Polycystic Ovary Syndrome (PCOS) affects up to 10% of women of reproductive age, characterized by hormonal imbalances and metabolic complications. Environmental factors potentially influence the biochemical expression of this condition. This study aims to examine the impact of urban versus rural environments on metabolite profiles in women with PCOS.

Methods

Thirty women aged between 18 and 40, diagnosed with PCOS according to the Rotterdam 2003 criteria, were recruited from June 2022 to May 2023, 16 from urban settings and 14 from rural settings. Serum samples were analyzed using liquid chromatography-tandem mass spectrometry. Principal component analysis and orthogonal partial least squares discriminant analysis were performed to identify metabolic patterns and

SUBMITTER: Patel J 

PROVIDER: S-EPMC12214864 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature