Development SPE-LC-MS/MS method for determination of WHO AWaRe Reserve antibiotics in hospital wastewater.

ABSTRACT: Overuse and inadequate legal regulation of the use of antibiotics have led to antimicrobial resistance, which threatens healthcare by reducing the effectiveness of treatments and promoting multidrug-resistant "superbugs". The World Health Organization created the AWaRe (Access, Watch, Reserve) classification to categorize antimicrobials according to their therapeutic value, emphasizing prudent use. The most important group in terms of protecting effectiveness is the Reserve group. The aim of the study was to develop a method for the determination of the following Reserve antibiotics in hospital wastewater: aztreonam, linezolid, meropenem, tigecycline, vaborbactam, cilastatin, fosfomycin, and ceftazidime. Twenty-six extraction procedures were tested and the one with the best recoveries for

SUBMITTER: Wilk J 

PROVIDER: S-EPMC12214922 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature