Targeting lipid raft-related stomatin to ameliorate osteoporosis in preclinical models.

ABSTRACT: Osteoporosis is a metabolic bone disease characterized by a disruption in the balance between bone resorption and formation. The specific role and mechanism of stomatin (STOM), a major component of lipid rafts, in regulating bone physiology remain unclear. This research identifies increased STOM expression in bone tissue of osteoporosis patients and ovariectomized mice. STOM-deficient mice show higher bone mass under both normal conditions and after ovariectomy. Furthermore, we clarify that STOM is a positive regulator of osteoclast differentiation. Through transcriptomic and bioinformatics approaches, our research reveals that inhibiting STOM increases antioxidant proteins and suppresses ROS-mediated transcriptional pathways in osteoclasts. Mechanistically, STOM interacts with Prdx1, prom

SUBMITTER: Tao H 

PROVIDER: S-EPMC12214925 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature