Single cell sequencing and computational findings reveal anti-estrogen receptor-positive breast cancer roles of formononetin.

ABSTRACT: Breast cancer is the second leading cancer type in women, accounting for 11.6% of all cancers. Recently, its incidence has increased in younger individuals. Estrogen receptors (ERs) play important roles in the development and progression of breast cancer by controlling hormone signaling. Therefore, targeting ERs is one of the most promising therapeutic strategies for treating ER-positive breast cancer. High heterogeneity contributes to the tumorigenicity, metastatic ability, and therapeutic resistance of breast cancer. However, drug discovery studies at the single-cell level are lacking. In the present study, we used single-cell sequencing data analysis, together with a network pharmacology approach, to determine the targets and molecular mechanisms of formononetin in ER-positive breast ca

SUBMITTER: Li B 

PROVIDER: S-EPMC12214957 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature