Anapc5 and Anapc7 as genetic modifiers of KIF18A function in fertility and mitotic progression.

ABSTRACT: The kinesin family member 18 A (KIF18A) is an essential regulator of microtubule dynamics and chromosome alignment during mitosis. Functional dependency on KIF18A varies by cell type and genetic context but the heritable factors that influence this dependency remain unknown. To address this, we took advantage of the variable penetrance observed in different mouse strain backgrounds to screen for loci that modulate germ cell depletion in the absence of KIF18A. We found a significant association at a Chr5 locus where anaphase promoting complex subunits 5 (Anapc5) and 7 (Anapc7) were the top candidate genes. We found that both genes were differentially expressed in a sensitive strain background when compared to resistant strain background at key timepoints in gonadal development. We also iden

SUBMITTER: Nesbit C 

PROVIDER: S-EPMC12214974 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature