Impact of severe splenic trauma and its management on the occurrence of infections in intensive care unit.

ABSTRACT:

Purpose

Severe trauma can be responsible for a major systemic inflammatory response followed by post-traumatic immunosuppression. Immune imbalance promotes infections and increases mortality. This risk could be further increased in case of impaired splenic immune function due to splenic trauma. The objective of this study was to evaluate whether severe splenic trauma increased infectious complications in trauma patients during intensive care unit (ICU) stay.

Methods

This was an observational, bicentric, retrospective, case-control study including patients admitted for severe trauma from January 2011 to December 2020 in two level 1 trauma centers. Patients with American Association for the Surgery of Trauma (AAST) ≥III splenic trauma (case) were matched (1:3) with patients wi

SUBMITTER: Polge N 

PROVIDER: S-EPMC12215103 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature