Endogenous and Extracellular Roles of a Tumor Suppressor miR-379-5p in Gastric Cancer.

ABSTRACT:

Introduction

MiRNAs play important roles in development of various cancers including gastric cancer. Exosomes are extracellular vesicles for translocating molecules. This study aimed to investigate the tumor suppressive roles of miR-379-5p in gastric cancer and to investigate the roles of exosomes in transporting miR-379-5p from intracellular to extracellular.

Methods

Fifty-three pairs of gastric cancer and non-tumor tissue samples were collected. Five cell lines were applied. Functional assays including cell proliferation, cell migration and invasion, and cell adhesion assay were performed. Targets of miR-379-5p were screened and validated by Western blot. Expressions of endogenous miR-379-5p in gastric cancer cells and exosomal miR-379-5p in cell culture medium were evalua

SUBMITTER: Liu MX 

PROVIDER: S-EPMC12215176 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature