Protein corona composition modulates uptake of polymeric micelles by colorectal cancer cells.

ABSTRACT: Protein corona formation on nanoparticles affects their biological interactions and fate. Polymeric micelles (PMs), preferred nanocarriers for poorly water-soluble drugs, have unclear behaviors in biological environments. This study examines the protein corona compositions of PMs formed from poly(ethylene oxide)-block-poly(ε-caprolactone) (PEO-PCL) and PEO-block-poly(α-benzyl carboxylate-ε-caprolactone) (PEO-PBCL) copolymers with varying degrees of polymerization after incubation in human plasma, and explores their relationship with cellular uptake by colorectal cancer cells. Traceable block copolymers were synthesized, self-assembled into PMs (44-99 nm, slightly negative zeta potentials), and characterized. Protein coronas were formed by incubating PMs with human plasma; pro

SUBMITTER: Sirazum M 

PROVIDER: S-EPMC12215469 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature