Histone lysine methyltransferases MLL3 and MLL4 direct gene expression to produce platelets efficiently.

ABSTRACT: Circulating blood platelets are responsible for maintaining hemostasis. They are released into blood vessels from mature megakaryocytes. Although several transcription factors have been reported to orchestrate the transcriptional programs required for platelet production, how chromatin regulators control these processes is still poorly understood. MLL3 and MLL4 are the main lysine methyltransferases responsible for the deposition of H3K4me1 histone marks at enhancers. MLL3 and MLL4 typically form complexes with other co-factors, such as PTIP. Recently, we showed that loss of PTIP leads to decreased platelet numbers in mice. Here, we find that, although MLL3/4 double deficiency does not alter megakaryopoiesis and endomitosis, the final step of megakaryocyte maturation is affected due to an

SUBMITTER: Gao G 

PROVIDER: S-EPMC12215508 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature