Predictive effect and clinical diagnosis significance of exosome-related genes for nonalcoholic fatty liver disease-related hepatocellular carcinoma.

ABSTRACT: Nonalcoholic fatty liver disease (NAFLD) is a multifactorial metabolic syndrome which could develop into hepatocellular carcinoma (HCC). Exosomes could mediate intercellular communications and play key roles in the occurrence and development of many diseases including NAFLD and HCC. However, expressions and roles of the genes related to exosomes in NAFLD-related HCC remain unclear. The objective of this study was to investigate the expressions and diagnostic values of exosome-related genes in NAFLD-related HCC. Firstly, two risk subgroups of patients with NAFLD-related HCC from the gene expression omnibus (GEO) database were identified based on exosome-related genes. High levels of memory CD4⁺ T cells and low expressions of immune checkpoint genes were observed in the group with

SUBMITTER: Ding X 

PROVIDER: S-EPMC12215628 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature