Integrative in Silico and in vitro validation suggest LINC00963 and SNHG15 as candidate biomarkers for coronary artery disease.

ABSTRACT: Despite notable advancements in prevention, medication, and treatment approaches, coronary artery disease (CAD) remains a significant challenge for healthcare systems and the economy. In relation to CAD, long non-coding RNAs (lncRNAs) can impact its development by influencing immune responses, affecting the functions of endothelial and vascular smooth muscle cells, and modifying lipid metabolism. Through the analysis of the GEO dataset (GSE42148), we identified differentially expressed genes (DEGs) and lncRNAs (DELs) in CAD patients. We performed functional enrichment and pathway analyses to clarify the roles of these DEGs. To investigate the interactions between DEGs and DELs, we created the lncRNA-mRNA interaction network. To investigate the interactions between DEGs and DELs, we constru

SUBMITTER: Saberiyan M 

PROVIDER: S-EPMC12215653 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature