Ocean acidification induces changes in circadian alternative splicing profiles in a coral reef fish.

ABSTRACT: Alternative splicing is a fundamental mechanism of gene expression regulation that increases mRNA diversity and can be partially regulated by the circadian clock. Time-dependent production of transcript isoforms from the same gene facilitates coordination of biological processes with the time of day and is a crucial mechanism enabling organisms to cope with environmental changes. In this study, we determined the impact of future ocean acidification conditions on circadian splicing patterns in the brain of fish, while accounting for diel CO₂ fluctuations that naturally occur on coral reefs. The temporal splicing pattern observed across a 24-hour period in fish from the control group was largely absent in those exposed to either stable or fluctuating elevated CO₂ condit

SUBMITTER: Suresh S 

PROVIDER: S-EPMC12215730 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature