Downregulation of UDP-glucose 6-dehydrogenase predicts adverse outcomes in patients with colorectal cancer and promotes tumorigenesis.

ABSTRACT: UDP-glucose 6-dehydrogenase (UGDH) is the key enzyme of glucuronic acid metabolism and a key mediator in several cancer developmental signaling pathways. However, the expression and function of UGDH in colorectal cancer (CRC) are unclear. Bioinformatics analysis was conducted to research the expression, diagnosis, prognosis, functional enrichment, genetic alterations, and immune characteristics of UGDH in CRC. Hematoxylin-Eosin staining, KI67 immunohistochemistry staining, and UGDH immunohistochemistry staining of clinical colon tissues were performed. The UGDH gene was knocked down in HCT-8 cells. CCK8 and cell wound scratch assays were further performed in UGDH wild-type and UGDH-knockdown HCT-8 cells. UGDH is markedly downregulated in CRC tissues compared to normal tissues, which predic

SUBMITTER: Wang M 

PROVIDER: S-EPMC12215741 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature