Regulation of the developmental programs in Toxoplasma by a novel SNF2L-containing chromatin remodeling complex.

ABSTRACT: Toxoplasma gondii is an extremely successful parasite infecting one third of the human population and numerous animals. It has a complex life cycle with multiple developmental stages that are key for its transmission and pathogenesis. But how the developmental programs are regulated is largely unknown. Here, we screen putative chromatin remodeling proteins in T. gondii and find that a novel complex containing an evolutionarily conserved ATPase SNF2L is critical for programming the parasite's development. This complex contains four core proteins and conditional depletion of three of them leads to similar expression changes of developmentally regulated genes, including increased transcription of genes involved in sexual commitment and development. Accordingly, depletion of SNF2L causes merog

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC12215852 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature