The effects of candidate probiotic strains on the gut environment in dextran sulfate sodium-induced colitis mouse.

ABSTRACT: Inflammatory bowel disease (IBD) is a chronic condition characterized by intestinal inflammation and dysbiosis, with limited treatment options and significant challenges in long-term management. This study investigated the therapeutic potential of novel strains belonging to Bifidobacterium longum and Limosilactobacillus species, in a dextran sodium sulfate (DSS)-induced mouse model of colitis. In this study, our primary objective was to determine whether ingestion of these strains alleviates colitis symptoms and, if so, to elucidate how they restored gut microbial balance and modulated microbial metabolic functions. In most probiotic-treated groups, colitis disease activity index scores were significantly improved and colon length was preserved, with strains CBA7106 and BBH exhibiting effi

SUBMITTER: Ahn K 

PROVIDER: S-EPMC12215883 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature