Extracellular vesicles derived from Lactobacillus gasseri GFC-1220 alleviate inflammation via the TLR4/NF-κB signaling pathway in LPS-stimulated RAW264.7 macrophages.

ABSTRACT: Studies on the impact of gram-positive extracellular vesicles have paved the way for novel medical advancements. These vesicles serve as efficient carriers of microbial molecules to target cells, thereby influencing human pathophysiological processes. Thus, this study aimed to investigate the anti-inflammatory properties of extracellular vesicles derived from Lactobacillus gasseri GFC-1220 (LEVs) in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. LEVs were characterized using transmission electron microscopy, nanoparticle tracking analysis, and dynamic light scattering measurements to examine their morphology, size, and concentration. We further assessed the anti-inflammatory effects of LEVs and their underlying mechanism in LPS-stimulated RAW264.7 macrophages. Our findings revea

SUBMITTER: Koh JA 

PROVIDER: S-EPMC12215889 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature