Windows of susceptibility to neonatal acute kidney injury and nephron loss in a rabbit model.

ABSTRACT: Nephrogenesis is completed before term birth, but preterm infants continue this process postnatally. It is unknown if preterm neonates are more susceptible to acute kidney injury (AKI) immediately after birth (during nephrogenesis) or later in postnatal development, and if this AKI timing impacts nephron number. Rabbits were exposed to gentamicin (100 mg/kg intraperitoneal) and indomethacin (5 mg/kg orally) on postnatal day (P) 0-3 (early-exposed) or P6-9 (late-exposed). Animals were euthanized three hours after last nephrotoxin dose or at 6 weeks of life. Histologic injury was assessed, and Kidney injury marker 1 (Kim1) expression was quantified. At 6 weeks, blood urea nitrogen (BUN) and serum creatinine (SCr) levels were measured. Ex vivo MRI imaging was performed with automated quantita

SUBMITTER: Indugula S 

PROVIDER: S-EPMC12215908 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature