Germline genetic scores associated with cancer gene expression and immune responses across multiple cancer types.

ABSTRACT:

Background

Cancer is a polygenic disease that involves the dysregulation of multiple biological events, including aberrant cell proliferation and evasion of immune responses, which collectively contribute to cancer development and progression. Although the polygenic risk score (PRS) has enabled assessment of the effects of cancer risk loci, the potential impact of other genetic variants with functional relevance to cancer biology remains largely unexplored.

Methods

We conducted a large-scale analysis of UK Biobank data, including 61,249 cancer cases and 254,203 controls of European ancestry across 16 cancer types. We assessed the impact of germline variants relevant to cancer gene expression and 33 cancer immune responses by constructing genetic scores (eQS: eQTL-specific ge

SUBMITTER: Cha S 

PROVIDER: S-EPMC12215933 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature