<i>A priori</i> Design of [Mn(i)-Cinchona] catalyst for Asymmetric Hydrogenation of Ketones and β-Keto carbonyl Derivatives.

ABSTRACT: Herein, we report an efficient [Mncinchona] chiral catalytic system for the asymmetric hydrogenation of ketones, demonstrating a broad substrate scope and high chemoselectivity. The catalyst selectively reduces ketones, while leaving other reducible functional groups, such as olefins, alkynes, nitriles, nitro groups, and esters, unaffected. The solid-state structure of [Mncinchona] complex revealed that the cinchona ligand acts as bi-dentate ligand, providing valuable insights into its coordination environment and reaction mechanism. DFT calculations suggest that hydrogen molecule activation assisted by water molecules occurs via a six-membered transition state, with enantioselectivity driven by preferential hydride transfer to the si face of the prochiral substrate, resultin

SUBMITTER: Paira S 

PROVIDER: S-EPMC12215956 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature