Mitochondrial haplogroup A2 is associated with increased COVID-19 mortality in an admixed Brazilian population.

ABSTRACT: Mitochondria play a crucial role in cellular respiration and immune responses. Mitochondrial DNA (mtDNA) haplogroups and variants have been associated with various diseases, including COVID-19. This study analyzed complete mtDNA sequences from 467 Brazilian patients with COVID-19 to investigate associations between mtDNA ancestry and mortality risk. Using classical statistical methods and a machine learning model, we identified key contributors to outcomes, with age as the primary risk factor, followed by male sex. Several mtDNA variants-663G, 1736G, 2706G, 3010A, 4248C, 4824G, 8027A, 8794T, and 10873C-were significantly associated with increased mortality risk. Most are characteristic of haplogroup A2, prevalent in populations with Native American ancestry. Notably, the 8027A allele, a no

SUBMITTER: Tavares GM 

PROVIDER: S-EPMC12215973 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature