Impaired intestinal calcium absorption and osteopathy in ICR/Mlac-hydro mice with hypoparathyroidism and severe hydronephrosis.

ABSTRACT: Abnormal fluid accumulation in the renal pelvis and calyces, with enlargement of the pelvicalyceal system, leads to a devastating disease known as hydronephrosis, which subsequently induces progressive renal impairment and mineral imbalance. Since the renal tubular cells play a role in the conversion of 25-hydroxyvitamin D₃ to 1,25-dihydroxyvitamin D₃ [1,25(OH)₂D₃], an important calciotropic hormone, we hypothesized that the ICR/Mlac-hydro mice with bilateral non-obstructive hydronephrosis and hypoparathyroidism plausibly manifested derangements of calcium and bone metabolism. The results showed that Mlac-hydro mice had reductions in the levels of intact parathyroid hormone, 1,25(OH)₂D₃ and fibroblast growth factor-23, along

SUBMITTER: Suntornsaratoon P 

PROVIDER: S-EPMC12216024 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature