Identification and validation of key target genes of penning formula for treating rat chronic endometritis model.

ABSTRACT: This study analyzed transcriptome sequencing data from rat samples, categorized into control (normal), model (chronic endometritis, CE), and test (treated with Penning Formula, PNF) groups, to identify key target genes of PNF in CE treatment and elucidate the specific mechanism of PNF treatment for CE. Differentially expressed genes (DEGs) between the model-control (DEGs1) and model-test (DEGs2) groups were compared, revealing 47 PNF-related genes (PRGs), primarily involved in stress response and prolactin signaling. These PRGs were cross-referenced with 909 target genes (TGs) of 25 active ingredients of PNF obtained from public databases, resulting in the identification of three key target genes: Bhmt, Scn10a, and Esr2. Further analysis, including functional pathway enrichment, chromosoma

SUBMITTER: Zhihui L 

PROVIDER: S-EPMC12216075 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature