Systematic screening of metabolic pathways to identify two breast cancer subtypes with divergent immune characteristics.

ABSTRACT: Due to the high heterogeneity among breast cancer (BRCA) patients, most individuals show a limited response rate to one specific treatment. The metabolic plasticity of BRCA cells is one of the main causes of their heterogeneity, affecting not only their own growth and function but also their metabolites have an impact on the tumor immune microenvironment (TIME). However systematic evaluation of metabolic pathways in BRCA is lacking. We identified BRCA metabolic subtypes (BCMS) by consensus clustering 26 KEGG/Reactome pathways in the TCGA BRCA discovery cohort (n = 1094). Nine independent bulk transcriptome cohorts (total n > 4000), including METABRIC and GEO datasets, were used for validation via random forest classification. To characterize BCMS, we applied an analytical framework encompa

SUBMITTER: Cheng X 

PROVIDER: S-EPMC12216186 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature