Single nucleus RNA-seq reveals the process from onset to chronic kidney disease in IgA nephropathy.

ABSTRACT: IgA nephropathy (IgAN) is a common form of glomerulonephritis. According to the established multi-hit theory of IgAN pathogenesis, the final hit is the mesangial deposition of IgA1-containing immune complexes, leading to characteristic pathological features such as mesangial cell proliferation and expansion of extracellular matrix. We analyzed several public transcriptomic datasets, including microarray and bulk RNA-sequencing, to identify pathway alterations in IgAN patients and progressors. We also generated our own single-nucleus RNA-sequencing dataset from IgAN kidney biopsies with normal or reduced estimated glomerular filtration rate and integrated it with a publicly available healthy control dataset to comprehensively examine cell type-specific changes during IgAN progression. Pathw

SUBMITTER: You JP 

PROVIDER: S-EPMC12216285 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature