Brain-wide input-output analysis of tuberal nucleus somatostatin neurons reveals hierarchical circuits for orchestrating feeding behavior.

ABSTRACT: Feeding is an innate behavior critical for survival but is also influenced by many non-nutritional factors such as emotion, social context and environmental conditions. Recently, tuberal nucleus somatostatin (^TNSST) neurons have been identified as a key feeding regulation node. To gain a deeper understanding of the ^TNSST neural networks, we quantitatively characterised the brain-wide input-output configuration of mice ^TNSST neurons using the VITALISTIC method (Viral Tracing Assisted by Light-Sheet microscope and Tissue Clearing) and single-cell projectomes by fluorescence micro-optical sectioning tomography (fMOST). We found that ^TNSST neurons receive direct inputs from and send outputs to a broad range of brain regions, including many cortical a

SUBMITTER: Senol E 

PROVIDER: S-EPMC12216382 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature