Preoperative TNF-α predicts uneventful postoperative outcomes in patients undergoing colorectal cancer surgery.

ABSTRACT: The development of novel biomarkers to predict postoperative complications (POCs) after colorectal cancer (CRC) surgery is essential, both for improving treatment outcomes and for facilitating the widespread use of same-day discharge following colectomy. This longitudinal observational study, a sub-study of a previous RCT, investigated the prognostic potential of a panel of novel biomarkers, including inflammatory cytokines (TNF-α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-17 A, INF-γ, IP-10, MCP-1, TGF-β1), alongside conventional biomarkers such as CRP and WBC levels, measured preoperatively and on postoperative day 6, for predicting POCs following CRC resection. Among 40 recruited patients, 38 were included in the final analysis. Patients who did not experience POCs had a signif

SUBMITTER: Rauduvyte K 

PROVIDER: S-EPMC12216408 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature