Spatiotemporal terahertz modulation enhances NMDAR-mediated miniature EPSCs.

ABSTRACT: N-Methyl-D-aspartate receptors (NMDAR) are essential for synaptic plasticity and cognitive function, making their modulation a promising strategy for treating disorders like schizophrenia and cognitive impairment. However, methods to selectively modulate NMDAR activity in the lesion's nucleus of the central nervous system remain limited. In this study, using whole-cell patch-clamp recordings, we demonstrated that frequency-specific (42.5 THz) terahertz irradiation significantly enhanced both the frequency and amplitude of NMDAR-mediated miniature excitatory postsynaptic currents (mEPSCs), a response closely linked to Ca²⁺ currents. The mechanism is elucidated via molecular dynamics (MD) simulations, revealing that 42.5 THz irradiation effectively alters the free energy landscape of Ca²⁺ pe

SUBMITTER: Jiang S 

PROVIDER: S-EPMC12216413 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature