Lavender Exosome-Like nanoparticles attenuate UVB-Induced Photoaging via miR166-Mediated inflammation and collagen regulation.

ABSTRACT: Excessive UVB exposure accelerates skin aging by triggering inflammatory responses and collagen degradation. In recent years, plant-derived extracellular vesicles (PDEVs) have attracted considerable attention for their ability to encapsulate and deliver bioactive molecules, showing therapeutic potential in various fields such as skin care, wound healing, immune regulation, cancer therapy, and drug delivery. In this study, we isolated lavender exosome-like nanoparticles (LELNs) and evaluated their protective effects against UVB-induced skin photoaging. LELNs were purified using differential and sucrose density gradient centrifugation, with characterization through dynamic light scattering (DLS), nanoparticle tracking analysis (NTA), and transmission electron microscopy (TEM). UVB-induced ph

SUBMITTER: Li S 

PROVIDER: S-EPMC12216414 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature