Aerobic and resistance exercise-regulated phosphoproteome and acetylproteome modifications in human skeletal muscle.

ABSTRACT: Despite indisputable benefits of different exercise modes, the molecular underpinnings of their divergent responses remain unclear. We investigate post-translational modifications in human skeletal muscle following 12 weeks of high-intensity aerobic interval or resistance exercise training. High-intensity aerobic training induces acetylproteome modifications including several mitochondrial proteins, indicating post-translational regulation of energetics machinery, whereas resistance exercise training regulates phosphoproteomic modifications of contractile/cytoskeletal machinery, consistent with greater strength. Furthermore, despite similar transcriptional responses to a single acute bout of aerobic and resistance exercise, more robust phosphoproteomic and metabolomic responses occur with

SUBMITTER: Pataky MW 

PROVIDER: S-EPMC12216477 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature