Exploration of shared pathogenic factors and causative genes in early-stage endometrial cancer and osteoarthritis.

ABSTRACT: Osteoarthritis (OA) has been implicated in the development and progression of early-stage endometrial cancer (EC), suggesting shared pathogenic factors between the two diseases. This study aimed to investigate the causal relationship between OA and EC and to identify causative genes common to both early-stage EC and OA. A Two-sample Mendelian randomization (MR) analysis was first performed to assess the causal relationship between OA and EC. Differentially expressed genes associated with early-stage EC and OA were identified using the limma package. Overlapping genes were extracted to determine common causative genes, followed by enrichment analysis. The causal relationship between these genes and EC was verified through Mendelian randomization (MR) of drug targets. Genes with diagnostic v

SUBMITTER: Bai Y 

PROVIDER: S-EPMC12216496 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature