Unraveling developmental gene regulation in holometabolous insects through comparative transcriptomics and proteomics.

ABSTRACT: Holometabolous insects undergo complex phenotypic changes during development in four major stages: egg, larva, pupa and adult. Such changes are typically driven by strong transcriptome and proteome dynamics, making this process an excellent system for comparing these two levels of regulation. Here, we provide a comprehensive paired transcriptome and proteome dataset of 17 timepoints across the developmental life cycle of the silkworm Bombyx mori. The analysis of this data revealed similarities and differences between transcriptional and post-transcriptional gene expression, enabling the identification of stage-specific characteristics. Specifically, the oxidative phosphorylation pathway was enriched in genes expressed especially in adults. We examined protein-transcript correlations and ch

SUBMITTER: Wilkens M 

PROVIDER: S-EPMC12216547 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature