Proteomic analysis of Buffalo milk somatic cells reveals metabolomic and immunological transitions during early lactation.

ABSTRACT: Buffalo milk is renowned for its nutritional and functional properties. Milk somatic cells protect the mammary gland, contribute to the functionality of the udder, and also aid in the health and development of newborn calves, particularly during the critical early lactation period. However, proteomic changes in buffalo milk somatic cells during the transition from colostrum to mature milk remain poorly understood. This study was formulated to characterize the proteomic dynamics of buffalo milk somatic cells using Liquid chromatography-tandem mass spectrometry (LC-MS/MS) during colostrum-to-mature milk transition and to reveal shifts in metabolic and immune functions. A total of 4,429 high-confidence proteins were identified in the colostrum and milk of buffaloes. Up-regulated proteins [P

SUBMITTER: Kittur PM 

PROVIDER: S-EPMC12216581 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature