An integrative modelling approach to the mitochondrial cristae.

ABSTRACT: Mitochondria are implicated in many cellular functions such as energy production and apoptosis but also disease pathogenesis. To effectively perform these roles, the mitochondrial inner membrane has invaginations known as cristae that dramatically increase the surface area. This works to provide more space for membrane proteins that are essential to the roles of mitochondria. While separate components of this have been studied computationally, it remains a challenge to combine elements into an overall model. Here, we present a comprehensive model of a crista junction from a human mitochondrion and the accompanying workflow to construct it. Our coarse-grained representation of a crista shows how various experimentally determined features of organelles can be combined with molecular modellin

SUBMITTER: Brown CM 

PROVIDER: S-EPMC12216777 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature