Characterisation of gut microbiota in Malaysian cancer patients using V3-V4 region of 16S rRNA gene sequencing.

ABSTRACT: Recent studies suggested a potential connection between gut microbiota changes and cancer onset. However, conflicting results make it challenging to understand the role of gut microbiota dysbiosis in cancer, particularly in underrepresented populations like those in Southeast Asia. To address this gap, we analysed the diversity and composition of gut microbiota in 65 faecal samples, which included 48 from cancer patients with various malignancies and 17 from healthy controls. Patients were categorised into four groups: symptomatic patients undergoing cancer treatment, asymptomatic pre-treatment and during cancer treatment, and healthy controls. Genomic DNA was extracted, and the V3-V4 region of the 16 S rRNA gene was sequenced. Our findings revealed significant differences in the alpha div

SUBMITTER: Sidi Omar SFN 

PROVIDER: S-EPMC12216863 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature