The apoptotic and anti-metastatic effects of niosome kaempferol in MCF-7 breast cancer cells.

ABSTRACT: Kaempferol (KMF) possesses notable anti-tumor bioactivity, which indicates its promising action in the therapy of gynecologic cancers. Here, we examined the therapeutic potential of the naturally occurring flavonoid kaempferol coated on niosome nanoparticles (NPs) and its impact on the breast cancer cell line MCF-7. Niosome NPs containing KMF were prepared by thin-layer hydration. The generated niosome/KMF NPs cytotoxicity on MCF-7 and MCF-10 cell lines were assessed by MTT assay. The physicochemical properties of the niosome/KMF NPs were characterized by SEM, DLS zeta potential, and FTIR. Flow cytometry was used to quantify primary and secondary apoptosis, necrosis and cell cycle arrest. Finally, the expression of apoptosis (Bax and caspase 3) and metastasis genes (ITGA5 and MMP2) was ana

SUBMITTER: Minaei S 

PROVIDER: S-EPMC12216897 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature