Diminished angiogenic capacity in the hippocampus compared to the cortex indicates regional vulnerability.

ABSTRACT: The hippocampus is one of the first regions affected in various neurodegenerative diseases. In this study, we investigated the vascular factors contributing to its susceptibility, aiming to elucidate the underlying vascular mechanisms. Utilizing publicly available single-cell datasets, we analyzed the differential expression of genes in the endothelial cells and other blood-brain barrier (BBB)-associated cells within the hippocampus and compared them to those in the cortex. The identified hub genes were further validated using naïve mouse and ischemia rat models. We identified differentially expressed genes (DEGs) in endothelial cells, pericytes, and astrocytes in the BBB. Subsequent gene ontology (GO) enrichment analysis and protein-protein interaction (PPI) network analysis identified ke

SUBMITTER: Li X 

PROVIDER: S-EPMC12217085 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature