The responses of HNSCC patients to immunotherapy are shown by two novel co-expression patterns.

ABSTRACT: Treatment of head and neck squamous cell carcinoma (HNSCC) is complex, with immunotherapy demonstrating potential yet facing challenges due to the tumor's unique immune microenvironment. Biomarker expression has been employed to predict immune responses, albeit with limited efficacy. We predicted that due to the complexity of the immune response, no singular biomarker could consistently forecast the efficacy of immunotherapy. Consequently, we implemented a multi-index strategy that encompassed a comprehensive study of the networks associated with HNSCC. Secretomes from 72 explants obtained from six HNSCC patients (comprising 72 secretome profiles: 18 untreated and 54 treated) were subjected to an information-theoretic analysis. The resultant phenotypes were corroborated in two external coh

SUBMITTER: Daher-Ghanem N 

PROVIDER: S-EPMC12217146 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature