Shared genetic architecture of posttraumatic stress disorder with cardiovascular imaging, risk, and diagnoses.

ABSTRACT: Patients with post-traumatic stress disorder face increased cardiovascular risk. This study examines shared genetic regions between post-traumatic stress disorder and 246 cardiovascular conditions across electronic health records, 82 cardiac imaging, and health behaviors defined by Life's Essential 8. Post-traumatic stress disorder is genetically correlated with cardiovascular diagnoses in 33 regions, imaging traits in 4 regions, and health behaviors in 44 regions. Potentially shared causal variants between post-traumatic stress disorder and 17 cardiovascular conditions were observed in 11 regions. Subsequent observational analysis in AllofUS cohort showed post-traumatic stress disorder is associated with 13 diagnoses even after accounting for socioeconomic factors and depression. Genetica

SUBMITTER: Shen J 

PROVIDER: S-EPMC12217169 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature