Translational medicine research on the role of key gene network modulation mediated by procyanidin B2 in the precise diagnosis and treatment of multiple sclerosis.

ABSTRACT:

Objective

The present study aimed to investigate the potential role and molecular mechanism of procyanidin B2 (PCB2) in the treatment of multiple sclerosis (MS), with the hope of providing novel strategies for the precision treatment of MS.

Methods

The target genes of PCB2 and the disease-related target genes of MS were gathered from databases like GEO, GeneCards, OMIM, and DisGeNET. R language was employed for the identification of differentially expressed genes (DEGs), unsupervised clustering analysis, immune infiltration analysis, weighted gene co-expression network analysis (WGCNA), Gene Ontology (GO) analysis, and gene set enrichment analysis (GSEA). Eight machine learning algorithms were employed to screen key genes, and nomograms and ROC curves were constructed to ass

SUBMITTER: Liu J 

PROVIDER: S-EPMC12217209 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature