Strictosamide and mitraphylline inhibit cancer cell motility by suppressing epithelial-mesenchymal transition via integrin α4-mediated signaling.

ABSTRACT: Epithelial-mesenchymal transition (EMT) is a critical process in cancer cell motility and metastasis. Monoterpene indole alkaloids (MIAs) have been widely investigated for biological activities, but rarely been explored for cell motility inhibition. This study aimed to discover natural products, especially focusing on MIAs, that inhibit EMT in cancer cells, based on our screening using multiple plant extracts. We found that an extract of the aerial parts of Uncaria scandens (Sm.) Wall. (Rubiaceae) decreased cancer cell motility. Targeted isolation exhibited eight MIAs. Among them, strictosamide and mitraphylline suppressed the invasion and migration of the cells. The alteration of the mRNA expression of the EMT effectors and transcription factors suggested that the EMT signaling pathway is

SUBMITTER: Varlı M 

PROVIDER: S-EPMC12217235 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature